多功能NaLuF4@Ag2S复合纳米探针制备及应用研究
李小龙，裴雅儒，梁瑞梅
( 山西师范大学 材料科学研究院，磁分子与磁信息材料教育部重点实验室，山西 临汾 041004)
摘 要 稀土氟化物上转换纳米晶作为新一代光学探针，由于其低声子能量、结构与性能稳定以及低制备工艺等优势，在生物成像、肿瘤早期诊断等诸多领域颇受关注。而具有灵敏、高效和副作用低等优点的Ag2S光热材料，在新型微创型肿瘤治疗应用中深受青睐。因此，构建集稀土氟化物与Ag2S纳米颗粒于一体的多功能平台在未来同时实现肿瘤检测和治疗方面具有重要意义。本文主要利用原位生长的方法成功制备具出有核-卫星结构的NaLuF4：Gd/Yb/Er@Ag2S（记为NaLuF4@Ag2S）纳米探针，并系统地进行形貌及晶相表征，光学和光热性能，生物毒性检测，以及光学和光热生物成像探究。研究结果表明该复合纳米探针具有优异发光性能和高效光热性能，成功实现光学生物成像和光热成像多功能应用。
关键词 稀土上转换；核-卫星结构；光学成像；光热成像
中图分类号：TB34;R318.08;TB383
文献标识码：Adoi:10.3969/j.issn.1000-6281.2021.06.004
Study on preparation and application of multifunctional NaLuF4@Ag2S composite nanoprobe
LI Xiao-long，PEI Ya-ru，LIANG Rui-mei
( Research Institute of Materials Science of Shanxi Normal University & Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education, Linfen Shanxi 041004, China）
Abstract As a new generation of optical probes, rare earth fluoride upconversion nanocrystals have attracted much attention in many fields such as biological imaging and early tumor diagnosis due to their advantages of low phonon energy, stable structure and performance and low preparation technology. Ag2S photothermal material, which has the advantages of sensitivity, high efficiency and low side effects, has been favored in the application of new minimally invasive tumor therapy. Therefore, it is of great significance to construct a multifunctional-platform integrating rare earth fluoride and Ag2S nanoparticles for the simultaneous realization of tumor detection and treatment in the future. In this paper, the NaLuF4: Gd/Yb/Er@Ag2S (denoted asNaLuF4@Ag2S)nano-probe with nucleus-satellite structure was successfully prepared by using theIn situ growth method. The morphology and crystal phase characterization, optical and photothermal properties, biological toxicity detection, as well as optical and photothermal biological imaging exploration were systematically carried out. The results show that the composite nanoprobe has excellent luminescence and high photothermal performance, and can successfully realize the multifunctional application of optical biological imaging and photothermal imaging.
Keywords rare earth upconversion; nuclear-satellite structure; optical imaging; photothermal imaging
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